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COX-2 Blockade in Cancer Prevention and Therapy (Cancer Drug by Randall E. Harris

By Randall E. Harris

The revelation that aspirin and aspirin-like compounds have notableantineo­ plastic homes has revolutionized melanoma study. COX-2 Blockade in melanoma Prevention and treatment chronicles the proof and offers fascinating new op­ portunities for using cyclooxygenase-2 (COX-2) blockade within the prevention and remedy of melanoma. The textual content is split largely into 5 components. First, an ancient evaluate files the medical discovery ofCOX-2 and the pharma­ ceutical improvement of nonsteroidal anti inflammatory medicinal drugs (NSAIDs) designed for selective COX-2 inhibition. the method during which crucial poly­ unsaturated fatty acids (PUF As) stimulate prostaglandin biosynthesis and melanoma improvement, and its interruption by way of COX-2 inhibition, is elucidated. this can be via a bit at the epidemiology of NSAIDs and cancers of the colon and breast, and different anatomic websites. those chapters mirror major melanoma defense because of the usual use of universal NSAIDs reminiscent of aspirin and ibuprofen. a piece on animal versions of carcinogenesis offers complete proof that common NSAIDs inhibit quite a few malignant neoplasms in vivo, and highlights contemporary findings which convey that COX-2 blockading brokers produce outstanding chemopreventive results opposed to colon melanoma and breast melanoma in addition to different malignancies. Genetic types are awarded confirming the severe function of COX-2 in carcinogenesis. part IV then discusses the molecular biology of COX -2 vis-a-vis the function of COX -2 and, to a lesser quantity, COX -1, in modulating a couple of very important approaches in molecular carcinogenesis equivalent to mutagen­ esis, mobile department, angiogenesis, mobilephone differentiation, and apoptosis.

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